Master Control Genes in Development and Evolution

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The Homeobox Story

Walter J. Gehring; Foreword by Frank Ruddie

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In this fascinating book, one of the world’s most eminent developmental biologists discusses some of the exciting new insights into how genes control development. Walter Gehring describes in vivid detail his essential contributions to the landmark discovery of the homeobox, a characteristic DNA segment found in the genes of all higher organisms from the fruitfly to humans, and he explains how this has provided the key to our modern understanding of development and evolution. The book thus becomes not only a lucid discussion of genetics but also an engaging description of the art of scientific investigation.

Gehring begins his story by looking at the work of the many researchers who laid the foundation for the fields of molecular, cellular, and developmental biology, providing insightful vignettes of past and present investigators. He then describes his laboratory’s hunt for the gene that caused odd mutations in the fruitfly—in which, for example, antennae on the head were transformed into legs. He explains that researchers eventually found that the same master control genes that dictate the body plan in flies also pattern human bodies, limbs, hands, heart, and brain. And he illustrates the universality of the genetic control of development by describing the development of the eye; eyes as different as those of humans, squids, and flies, he shows, develop under the same master control gene.

Walter J. Gehring is professor in the department of cell biology at the University of Basel, Switzerland. He recently shared the March of Dimes Prize for research in developmental biology.

"Master Control Genes in Development and Evolution is a very interesting journey deep into one of the most exciting fields in contemporary biology, through the personal view of one of its most outstanding participants."—Fernando Casares, Quarterly Review of Biology

"The most fascinating aspect of Master Control Genes in Development and Evolution is Gehring’s genuine amusement with science, embellished by intriguing stories about his colleagues. The scientific information is plainly presented and basic, so that even those who are unfamiliar with developmental genetics can understand it."—Leonard Zon, New England Journal of Medicine

"Master Control Genes in Development and Evolution offers a vivid introduction to recent findings on how genes control development. In reading it, the layperson will also learn a great deal about the process of discovery through Gehring’s particularly warm and personal perspective. Developmental biologists might not care as much about the technical descriptions, but they, too, will enjoy Gehring’s accounts, which may seem like looking back at old family movies from their youth."—Claude Desplan, Science

"In Master Control Genes, Gehring writes clear and accessible prose, free of the acronyms and stilted jargon of most scientific text."—William McGinnis, Nature

ISBN: 9780300074093
Publication Date: November 10, 1998
254 pages, 6 1/8 x 9 1/4
111 b/w + 8 color illus.
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